DIGITAL ARCHIPELAGO

‘Genetic optimization of stem cells for cardiomyoplastic therapy’

Biomedicine and Health

Biomedical Research

2007

Stem cell therapy represents a promising approach for cardiovascular disease. Pluripotential stem cells (MPC) delivered successfully to the heart can replace and/or repair the damaged myocardium (cardiomyoplasty), but the limiting steps for implementation of this therapeutic strategy are the development of viable sources of autologous stem cells and of methods to foster their delivery and implantation in the heart via the bloodstream.

DIRECTOR

Antonio Bernad Miana;David Curiel

COLLABORATING INSTITUTIONS

Centro Nacional de Investigaciones Cardiovasculares

DESCRIPTION

Stem cell therapy represents a promising approach for cardiovascular disease. The goals of this project are to develop viral vectors (adenovirus) for use in modifying MPC so as to augment their delivery and implantation in the heart, and to show that genetically modified MPC home preferentially to the specified target both in vitro and in vivo.