DIGITAL ARCHIPELAGO

‘Research on mechanisms of breast cancer metastasis’

Biomedicine and Health

Biomedical Research

2010

Breast cancer is a remarkably heterogeneous disease, but subsets of tumors show recurrent patterns of transcriptional, genomic, and biological abnormality. Understanding how genes in these “patterns” collectively function in an otherwise heterogeneous biological setting to enable progression and modulate response to therapy is critical to improve management of the disease.

DIRECTOR

Joan Guinovart

COLLABORATING INSTITUTIONS

IRB Barcelona

DESCRIPTION

In particular, this study will examine how the ER pathway contributes in leading molecular events in breast cancer metastasis.

Specific objectives:

Objective 1: To characterize novel ER-positive breast cancer metastatic derivatives.
Objective 2: To establish the role of RERG as a metastasis suppressor in ER-positive breast cancer.
Objective 3: To test the hypothesis that ER status influences the choice of metastatic rnechanisrns.