Marcelo Sanmartín (Hospital Universitario Ramón y Cajal); Borja Castejón (Hospital La Zarzuela); Carmen Calles, Rafael Ramírez, Ignacio Hernández and Javier Díez (Francisco de Vitoria University); Marta Saura Redondo (University of Alcalá).
A rapid response is crucial, since the longer it takes until the patient is treated the larger the necrotized area. This project seeks to minimize the risks arising from oxygen deprivation in myocardial infarction using a new technology-driven approach. The goal, Zaragoza explains, is to limit the necrotized area and stop it progressing.
To this end, the team will employ non-invasive molecular imaging tools, including magnetic resonance, to visualize the myocardial damage. They will also explore ways to block a protein that triggers a cascade of effects leading to cardiomyocyte destruction, by injecting nanoparticles in a porcine model.
This project may lay the groundwork for a clinical study in patients aimed at limiting the impact of heart failure and improving their quality of life.