“Acceptance Speech” Frontiers of Knowledge Award 2019 in Biology and Biomedicine

Acceptance speech by David M. Sabatini, winner of the 2019 Frontiers of Knowledge Award in Biology and Biomedicine, who was honored alongside Michael N. Hall for their contributions to the discovery of the mTOR signaling pathway, a fundamental molecular mechanism that regulates cell growth in response to nutrient availability. His research led to the identification of this protein in mammalian cells and advanced our understanding of its role in physiological processes related to metabolism, cancer and aging.

Sabatini discusses the potential of the mTOR pathway as a therapeutic target for age-related diseases and reflects on the interest in rapamycin for its possible effects on longevity. He notes that some people are already taking this drug in the hope of extending their lives, although its potential applications against aging still require further research. He also highlights the po

Acceptance speech by David M. Sabatini, winner of the 2019 Frontiers of Knowledge Award in Biology and Biomedicine, who was honored alongside Michael N. Hall for their contributions to the discovery of the mTOR signaling pathway, a fundamental molecular mechanism that regulates cell growth in response to nutrient availability. His research led to the identification of this protein in mammalian cells and advanced our understanding of its role in physiological processes related to metabolism, cancer and aging.

Sabatini discusses the potential of the mTOR pathway as a therapeutic target for age-related diseases and reflects on the interest in rapamycin for its possible effects on longevity. He notes that some people are already taking this drug in the hope of extending their lives, although its potential applications against aging still require further research. He also highlights the possibilities of targeting this pathway to develop treatments for cancer and neurodegenerative diseases.