On the occasion of receiving the 3rd BBVA Foundation Frontiers of Knowledge Award in Biology and Biomedicine, medical researcher Shinya Yamanaka explains how he succeeded in reprogramming somatic cells into induced pluripotent stem cells (iPS), a breakthrough that opens the door to new therapies and drug discovery. He notes that the first clinical trials using iPS cells are already underway and that their therapeutic use may take around a decade, while their application in drug development is more immediate. He also highlights that the main challenge remains ensuring their safety and preventing tumor formation.
The BBVA Foundation Frontiers of Knowledge Award in the Biology and Biomedicine category has been granted, in its third edition, to Japanese scientist Shinya Yamanaka for showing that it is possible to reprogram differentiated cells back into a state that is characteristi
On the occasion of receiving the 3rd BBVA Foundation Frontiers of Knowledge Award in Biology and Biomedicine, medical researcher Shinya Yamanaka explains how he succeeded in reprogramming somatic cells into induced pluripotent stem cells (iPS), a breakthrough that opens the door to new therapies and drug discovery. He notes that the first clinical trials using iPS cells are already underway and that their therapeutic use may take around a decade, while their application in drug development is more immediate. He also highlights that the main challenge remains ensuring their safety and preventing tumor formation.
The BBVA Foundation Frontiers of Knowledge Award in the Biology and Biomedicine category has been granted, in its third edition, to Japanese scientist Shinya Yamanaka for showing that it is possible to reprogram differentiated cells back into a state that is characteristic of pluripotent cells. His work has accelerated the possibility of translating regenerative medicine from the bench to the clinic
00:00 Introduction
00:14 What led you to challenge one of the dogmas of biology — the idea that cells cannot be reprogrammed and that their fate cannot be reversed?
00:49 When do you think iPS cells will be able to be used for therapy?
01:23 And what about in the field of drug discovery?
01:51 What are the main obstacles to the use of iPS cells?
